An asymmetric route to 2,3-epoxy-syn-1,4-cyclohexane diol derivatives using ring closing metathesis (RCM)
نویسندگان
چکیده
An asymmetric route for the synthesis of highly functionalized 2,3-epoxy-syn-1,4cyclohexane diol derivatives present in some polyketide natural products has been developed. The key step involves RCM of an appropriately constructed 1,7-dienol derived from D-mannitol to cyclohexane1,4-diol followed by its stereoselective epoxidation.
منابع مشابه
Hybrid macrocycle formation and spiro annulation on cis-syn-cis-tricyclo[6.3.0.02,6]undeca-3,11-dione and its congeners via ring-closing metathesis
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